References

1. Garrett S, Johnson L, Drisko CH, et al. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol. 1999;70:490-503.
2. Garrett S, Adams DF, Bogle G, et al. The effect of locally delivered controlled-release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months. J Periodontol. 2000;71:22-30.
3. Red Bacteria Reduction, Dr. Walker, University of Florida; 45 subject well-controlled clinical study; Data on File, TOLMAR Inc.
4. Machion L, Andia DC, Lecio G, et al. Microbiological changes with the use of locally delivered doxycycline in the periodontal treatment of smokers. J Periodontol. 2004;75:1600-1604.
5. Machion L, Andia DC, Lecio G, et al. Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a 2-year follow-up. J Periodontol. 2006;77:606-613.
6. Stoller N, Johnson L, Trapnell S, et al. The pharmacokinetic profile of a biodegradable controlled release delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva and serum. J Periodontol. 1998;69:1085-1091.
7. In clinical trials, ATRIDOX was generally well-tolerated. Side effects were similar to those of placebo. The most common side effects were: headache, common cold, gum discomfort, pain or soreness, toothache, and tooth sensitivity. ATRIDOX should not be used by patients who are hypersensitive to doxycycline or any other drugs in the tetracycline class. The use of drugs in the tetracycline class during tooth development may cause permanent discoloration of the teeth. Tetracycline drugs, therefore, should not be used in pregnant women, unless other drugs are not likely to be effective or are contraindicated.
8. Garrett S, Polson AM, Stoller NH, et al. Comparison of a bioabsorbable GTR barrier to a non-absorbable barrier in treating human class II furcation defects. A multicenter parallel design randomized singel blind trial. J Periodontol 1997, 7:667-675.
9. Wennstrom JL, Newman HN, MacNeill SR, et al. Utilisation of locally delivered doxycyline in non-surgical treatment of chronic periodontitis. A comparative multi-center trial of 2 treatment approaches. J Clin Periodontol 2001, 28: 753-761.
10. Wolinsky LE, Camago PM, Polson AM, et al. The Significance of prior mechanical therapy for changes of periodontal status achieved by local delivery of a doxycycline hyclate containing gel. J Clin Periodontol 2001, 28:1115-1120.
11. Post Hoc analysis of patients reported in Garrett S, Johnson L, Drisko CH, et al. Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol. 1999;70:490-503.
12. Walker C, Godowski K, Borden L, et al. The Effects of Sustained Release Doxycycline on the Anaerobic Flora and Antibiotic-Resistant Patterns in Subgingival Plaque and Saliva. J Periodontol 2000; 71: 768-774.

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