Elimination of ATRIDOX

Question

How is ATRIDOX eliminated from the body?

Answer

ATRIDOX® is composed of the polymer, poly-DL-lactide (PLA) and the solvent, N-methyl-2-pyrrolidone (NMP). After ATRIDOX is applied to the periodontal gum pocket, the NMP solvent diffuses out of the polymer mixture into the oral fluids. NMP is readily absorbed through oral tissues, where it is metabolized and mostly excreted in the urine in 24 hours. PLA hardens in the pocket and slowly disintegrates by hydrolysis or is expelled through brushing, flossing, and eating. PLA is absorbed through tissues. PLA is metabolized (hydrolyzed) to lactic acid and then eliminated by the body as water and carbon dioxide.

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Dental Products ATRIDOX Gum Disease Clinical Results Applying ATRIDOX Home Care for ATRIDOX Package Insert Reimbursement & Claims Office Materials and Forms FAQs All Questions Application Contraindications Post Application Preparation ATRISORB & ATRISORB-D	Elimination of ATRIDOX Question How is ATRIDOX eliminated from the body? Answer ATRIDOX® is composed of the polymer, poly-DL-lactide (PLA) and the solvent, N-methyl-2-pyrrolidone (NMP). After ATRIDOX is applied to the periodontal gum pocket, the NMP solvent diffuses out of the polymer mixture into the oral fluids. NMP is readily absorbed through oral tissues, where it is metabolized and mostly excreted in the urine in 24 hours. PLA hardens in the pocket and slowly disintegrates by hydrolysis or is expelled through brushing, flossing, and eating. PLA is absorbed through tissues. PLA is metabolized (hydrolyzed) to lactic acid and then eliminated by the body as water and carbon dioxide.

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