ATRIDOX Locally Applied Antibiotic Gel

For the Treatment of Chronic Adult Periodontitis

ATRIDOX® (doxycycline hyclate 10%) is a major advancement in the treatment of periodontal disease (gum disease). It is a locally applied antibiotic (LAA) that is placed gently below the gum line into periodontal pockets where bacteria thrive.

ATRIDOX is applied with a syringe into the infected tooth pocket (the space between the tooth and gum) by your dental professional. ATRIDOX contains an antibiotic, doxycycline hyclate. ATRIDOX is an easy-to-use gel that flows to the bottom of pockets and fills even the smallest spaces between teeth and gums. After ATRIDOX is applied into the infected pocket, it hardens upon contact with oral fluids (saliva) to a wax-like substance. The antibiotic is slowly released into the surrounding infected tooth pocket for 21 days.⁶ In clinical studies, ATRIDOX has been shown to improve the health of your gums and to help stop the advancement of gum disease.

The only locally applied antibiotic (LAA) gel that flows deeply into infected pockets.

Flows freely and easily to the bottom of pocket to adapt to root morphology
Controlled release of doxycycline for a period of 21 days
Bioabsorbable- no removal required
Allows precise placement for targeted therapy
Dosing flexibility allows for treatment of multiple tooth sites with a single syringe

In clinical trials, ATRIDOX was generally well-tolerated. Side effects were similar to those of placebo. The most common side effects were: headache, common cold, gum discomfort, pain or soreness, toothache, and tooth sensitivity. ATRIDOX should not be used by patients who are hypersensitive to doxycycline or any other drugs in the tetracycline class. The use of drugs in the tetracycline class during tooth development may cause permanent discoloration of the teeth. Tetracycline drugs, therefore, should not be used in pregnant women, unless other drugs are not likely to be effective or are contraindicated.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

ATRIDOX ® is a registered trademark of TOLMAR Inc.

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Dental Products ATRIDOX Gum Disease Clinical Results Applying ATRIDOX VIDEO: Applying Atridox Home Care for ATRIDOX Package Insert Reimbursement & Claims Office Materials and Forms FAQs ATRISORB & ATRISORB-D Store	ATRIDOX Locally Applied Antibiotic Gel For the Treatment of Chronic Adult Periodontitis ATRIDOX® (doxycycline hyclate 10%) is a major advancement in the treatment of periodontal disease (gum disease). It is a locally applied antibiotic (LAA) that is placed gently below the gum line into periodontal pockets where bacteria thrive. ATRIDOX is applied with a syringe into the infected tooth pocket (the space between the tooth and gum) by your dental professional. ATRIDOX contains an antibiotic, doxycycline hyclate. ATRIDOX is an easy-to-use gel that flows to the bottom of pockets and fills even the smallest spaces between teeth and gums. After ATRIDOX is applied into the infected pocket, it hardens upon contact with oral fluids (saliva) to a wax-like substance. The antibiotic is slowly released into the surrounding infected tooth pocket for 21 days.⁶ In clinical studies, ATRIDOX has been shown to improve the health of your gums and to help stop the advancement of gum disease. The only locally applied antibiotic (LAA) gel that flows deeply into infected pockets. Flows freely and easily to the bottom of pocket to adapt to root morphology Controlled release of doxycycline for a period of 21 days Bioabsorbable- no removal required Allows precise placement for targeted therapy Dosing flexibility allows for treatment of multiple tooth sites with a single syringe In clinical trials, ATRIDOX was generally well-tolerated. Side effects were similar to those of placebo. The most common side effects were: headache, common cold, gum discomfort, pain or soreness, toothache, and tooth sensitivity. ATRIDOX should not be used by patients who are hypersensitive to doxycycline or any other drugs in the tetracycline class. The use of drugs in the tetracycline class during tooth development may cause permanent discoloration of the teeth. Tetracycline drugs, therefore, should not be used in pregnant women, unless other drugs are not likely to be effective or are contraindicated. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. ATRIDOX ® is a registered trademark of TOLMAR Inc.

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